Introduction to Base Quality Score Recalibration (BQSR)

Thanks to Chris Hartl for writing the initial implementation of BQSR for ADAM and for taking the time to share his knowledge of BQSR with me over cappuccino at People’s Cafe. Hopefully this post will help others who are trying to understand how BQSR works. Drop a comment if you have any questions. DNA sequencing machines provide an estimate of the quality of each base (e.g. A, C, T or G) that they read. [Read More]